Altered Levels of Fibrinogen in Relation to the Pathophysiology of Recurrent Spontaneous Abortions

Introduction: Recurrent Spontaneous Abortion (RSA) is one of the most common complications of pregnancy and is a major healthcare concern for the medical fraternity. Women experiencing recurrent pregnancy loss are a heterogenous population, therefore specific markers are necessary to identify those who will respond to various treatments. During normal healthy pregnancy there are substantial changes in the haemostatic system. This results in variations in the plasma levels of many clotting factors in the blood coagulation cascade. Any change in these factors reflects hypercoagulability and therefore, represents an imbalance in the haemostatic system which leads to thrombotic haemostasis defects. In humans, fibrinogen is required to support pregnancies by maintaining haemostatic balance. Data sources: Some studies have shown that women with thrombophilias have 66-83% recurrence rate of fetal loss in subsequent pregnancies and also that fibrinogen deficiencies result in abortions in the early gestational period. Objective: However none of the studies have confirmed the role of fibrinogen levels in the context of RSA. Measuring the altered levels of fibrinogen to predict occurrence of RSA, could be a major direction to be followed to gain insight into the thrombogenic potential of this protein. Results and conclusion: The information about the thrombogenic potential of this protein could inspire new strategies against the thrombotic complications of RSA.